SHANU CEFT CEFTRIAXONE

THERAPEUTIC CATEGORY

Ceftriaxone is a third-generation cephalosporin antibiotic.

PHARMACOLOGICAL CLASSIFICATION

Broad and medium-spectrum antibiotics

PHARMACOLOGICAL ACTION

Ceftriaxone is a broad-spectrum cephalosporin with a long plasma elimination half-life of approximately 8 hours in normal adults.

INDICATIONS

SHANU – CEFT 2 gm (Ceftriaxone for Injection USP 2 gm) (Veterinary) is indicated for treating serious infections, particularly against susceptible Enterobacteriaceae that are not susceptible to other less expensive agents or when aminoglycosides are not indicated (due to their potential toxicity). Its long half-life, good CNS penetration, and activity against Borrelia burgdorferi also have made it a potential choice for treating Lyme disease.

CONTRAINDICATIONS

Only prior allergic reaction to cephalosporins contraindicates ceftriaxone’s use. In humans documented hypersensitive to penicillin, up to 16% may also be allergic to cephalosporins. The veterinary significance of this is unclear.

Although bleeding times have only been reported rarely in humans, ceftriaxone should be used with caution in patients with vitamin K utilization or synthesis abnormalities (e.g., severe hepatic disease).

ADVERSE REACTIONS

Because veterinary usage of ceftriaxone is very limited, an accurate adverse effect profile has not been determined. The following adverse effects have been reported in humans and may or may not apply to veterinary patients: hematologic effects, including eosinophilia (6%), thrombocytosis (5%), leukopenia (2%) and more rarely, anemia, neutropenia, lymphopenia, and thrombocytopenia. Approximately 2-4% of humans get diarrhea. Very high dosages (100 mg/kg/day) in dogs have caused a “sludge” in bile. Hypersensitivity reactions (usually a rash) have been noted. Increased serum concentrations of liver enzymes, BUN, creatinine, and urine casts have been described in about 1-3% of patients. When given IM, pain may be noted at the injection site.

DOSAGE AND ADMINISTRATION

Medication should never be administered without first consulting your veterinarian.

In dogs, the usual dose is 7.5 to 25 mg per pound (15 to 50 mg/kg) every 12 to 24 hours intramuscularly or intravenously.

In cats, the usual dose is 12.5 to 25 mg per pound (25 to 50 mg/kg) every 12 hours intramuscularly, intravenously, or intraosseously.

After receiving ceftriaxone, many pets are sent home with a prescription of an oral cephalosporin, similar to ceftriaxone.

The duration of administration depends on the condition being treated, response to the medication, and the development of any adverse effects. Be certain to complete the prescription unless specifically directed by your veterinarian. Even if your pet feels better, the entire treatment plan should be completed to prevent relapse or prevent the development of resistance.

OVERDOSAGE

There is no specific antidote.

Overdoses should be monitored and treated symptomatically and supportively if required.

COMPATIBILITY AND STABILITY:

Ceftriaxone for Injection should be stored at 30°C or below. Reconstituted Ceftriaxone I.M is stable for 24 hours at 25°C and for 3 days if refrigerated at 4 °C.

Reconstituted I.V. solution is stable for 3 days at 25°C and for 10 days if refrigerated at 4 °C.

Frozen solutions should be thawed at room temperature before use and discarded after use. Do not re-freeze.

Ceftriaxone solution should not be mixed with other antimicrobial agents.

HOW SUPPLIED

SHANU-CEFT 2 gm (Ceftriaxone for Injection USP 2 gm) (For Veterinary Use) is available in Combi pack of 20 mL (USP Type III) flint glass vial with sterilized water for injections BP- 20 ml ampoule packed in a carton with literature.

SHELFLIFE: 36 Months

STORAGE: Store in a cool place at a temperature below 30°C

Keep out of the reach of children

Withdrawal period: Meat: 14 days, Milk: 72 hours