INDICATIONS

G.DOXYNOR is particularly indicated for the prevention and treatment of diseases which affect the respiratory and digestive tract in poultry such as CRD, Air sacculitis, Coryza, Colibacillosis, Synovitis, Arthritis, and Salmonellosis.

ADMINISTRATION AND DOSAGE

Poultry: 1 g per 2 liters of drinking water daily for 4-5 days.

• Calves, Kids & Lambs: 10-20mg per kg B.W., twice daily for 3-5 days.
• SWINE: 2.5g per 100kg body weight twice daily for 3 to 5 days or 1g per 2 litres of water.

CONTRAINDICATION

Hypersensitivity to aminoglycosides and/or tetracyclines, renal dysfunctions, vestibular-, ear- or visus dysfunctions, liver dysfunctions, combination with potential nephrotoxic or muscle paralyzing medicines.

PHARMACOLOGICAL ACTIONS

Gentamycin is an antibiotic belonging to the group of aminoglycosides. It has bactericidal activity against Gram-positive and Gram-negative bacteria (including Pseudomonas spp, Klebsiella spp., Enterobacter spp., Serratia spp., E. Coli, Proteus spp., Salmonella spp., Staphylococci). Furthermore, it is active against Campylobacter fetus subsp jejuni and Treponema hyodysenteriae. Gentamycin may be active against bacteria, which are resistant to other aminoglycoside antibiotics (like neomycin, streptomycin, kanamycin). Doxycycline is a tetracycline derivative, with bacteriostatic action against a large number of Gram-positive and Gram-negative bacteria (like Staphylococci spp., Haemophilus influenza, E. coli, Corynebacteria, Bacillus anthracis, some Clostridia spp., Actinomyces spp., Brucella spp., Enterobacter spp., Salmonella spp., Shigella spp., and Yersinia spp. It acts also against Mycoplasma spp., Rickettsiae, and Chlamydia spp. Absorption after oral administration of doxycycline will be good and therapeutic levels will be attained quickly and resisted for a longer period, due to a relatively long serum half-life time. Doxycycline has a great affinity to lung tissues, therefore it is recommended especially for respiratory tract infections.

SIDE-EFFECTS

Kidney damage and/or ototoxicity, hypersensitivity reactions like gastro-intestinal disturbances or changes of intestinal flora.

WITHDRAWAL PERIOD

Poultry: Chicken: 14 days.

Eggs: Do not use in layers producing eggs for human consumption.

Calves, Kids, Lambs: Meat and Offals: 21 days (large animals).

Milk: Do not use in animals producing milk for human consumption.