INDICATIONS

D.Colinorx is particularly indicated for the treatment of diseases of Gastrointestinal and expiratory infections caused by micro-organisms sensitive to doxycycline and colistin in combination with Ambroxol as mucolytic agent Caused by Gram-positive and gram – bacteria such as Colibacillosis, salmonellosis, Infectious Coryza, Air Saculitis, Infectious synovitis, Clostridial dermatitis, Necrotic enteritis, Mycoplasma, Chlamydia, and Rickettsia.

PHARMACOLOGICAL

D.Colinor Extra is a combination of two antibiotics and an expectorant.

Doxycycline: It belongs to the group of tetracyclines and acts bacteriostatic against many Gram-positive and Gram-negative bacteria like Bordetella, Campylobacter, E. coli, Haemophilus, Pasteurella, Salmonella, Staphylococcus, and Streptococcus spp. Doxycycline is also active against Chlamydia, Mycoplasma, and Ricketta spp. The action of doxycycline is based on the inhibition of bacterial protein synthesis. Doxycycline has a good affinity towards the lungs and is therefore specially useful for the treatment of bacterial respiratory infections.

Colistin: It is an antibiotic from the group of polymyxins with biocidal action against mainly Gram-negative bacteria like aerobic bacteria, E4446mophilus, and Salmonella spp. Polymyxins interact strongly with spholipids and penetrate into and disrupt the structure of cell membranes. Administered orally, colistin is poorly resorbed and, therefore, performs its action predominantly gastrointestinally.

Ambroxol hydrochloride:

It is a mucolytic expectorant that removes excess mucous in the respiratory tract and restores the physiological clearance mechanisms of the respiratory passage.

CONTRAINDICATIONS

• it should not be given to Animals with renal impairment

It should not be given to animals suffering from hepatic dysfunction.

• Avoid Concurrent administration of penicillins, cephalosporins, quinolones, and cycloserine.

ADMINISTRATION AND DOSAGE

For oral administration

Calves, goats, and sheep: Twice daily 1 g per 20 kg body weight for 4-5 days.

Poultry: 1 g/2 liters of drinking water daily for 4-5 days.

Swine: 1 g per 1 liter of drinking water for 4-5 days.

Note: For pre-ruminant calves, lambs, and kids only and not for Adult

SIDE EFFECTS

Discoloration of teeth in young animals or hypersensitivity reactions may occur. Digestive alterations may appear, such as intestinal dysbiosis, accumulation of gases, or mild diarrhea.

WITHDRAWAL PERIOD

Chicken: 7days

Eggs: 14 days

Calves, Kids, and Lamb: 14 days.

Swine: 8 days.

STORAGE:

Store in a dark, dry, and cool place at room temperature not exceeding 30 °C. Strictly keep away from light and avoid heat exposure.