CLOSINOR 5% INJECTION | Dewormer for Cattle & Sheep

Description:

CLOSINOR 5% Injection is a synthetic anti-parasitic agent. It is highly effective against liver fluke, bloodsucking nematodes and larval stages of some arthropods in sheep and cattle.

Closinor decouples the mitochondrial oxidative phosphorylation, which leads to the inhibition of ATP synthesis.

That causes a significant change in the energy metabolism, and as a consequence the death of the parasite.

Mode of Action

CLOSINOR works by decoupling mitochondrial oxidative phosphorylation in parasites. This inhibits ATP synthesis, disrupting energy metabolism and leading to parasite death. The targeted action ensures minimal risk of resistance and maximum efficacy.

Indications:

CLOSINOR 5% Injection is used for the treatment and prevention of several infections caused by parasites sensitive to Closinor like Fasciola hepatica, Fasciola gigantica, Haemonchus concortus, Haemonchus placei, Bunostomum phlebotomum, Oesophagostomum radiatum, and Strongyloides papillosus in cattle and sheep.

• In cattle: treatment and prevention of infections caused by parasites sensitive to Closinor like Hypoderma bovis
• In sheep: treatment and prevention of infections caused by parasites sensitive to Closinor like Paramphistomum spp. Chabertia ovina, and Oestrus ovis.

• Why Choose CLOSINOR?

  • Highly potent antiparasitic formula

  • Proven efficacy against flukes and nematodes

  • Enhances feed conversion and animal performance

  • Supports herd health and profitability

Contra-Indications:

Hypersensitivity to Closinor.

• Do not use for intravenous or intramuscular administration.
• Do not use in cattle or ewes producing milk for human consumption, including in the dry period.
• Do not use in the last trimester of pregnancy in heifers, which are intended to produce milk for human consumption.
• Do not use within 1 year prior to the first lambing in ewes intended to produce milk for human consumption.

Side effects

• Hyper-acute anaphylactic reactions in cattle.
• Hypersensitivity reactions.
• Overdoses can cause reduced visibility or blindness, anorexia, lack of coordination, and general weakness.

• Administration & Efficacy

  Administered via injection, CLOSINOR provides fast absorption and systemic distribution, reaching parasites in difficult-to-access tissues like the liver and lungs. It ensures rapid relief, improved animal health, and higher productivity.

Dosage and Administrations

For subcutaneous administration:

• Sheep, cattle less than 200 kg: 1 ml per 10 kg bodyweight.
• Cattle of 200 to 400 kg: 20 ml.
• Cattle over 400 kg: 20 ml plus 5 ml per 100 kg of extra body weight.

Do not administer more than 20 ml in cattle per injection site.

Withdrawal Period:

Cattle:

• Meat and offal: 49 days:
• Milk: Not fit for human consumption

Sheep:

• Meat and Offal: 28 days
• Milk: Not fit for human consumption

Storage:

Store in a dry, dark place below 25 °C and protect from sunlight

Keep out of reach of children