CALGONATE INJECTION

80.00800.00

Calgonate Injection can be used to treat tetany caused by therapeutic calcium, acute hypocalcemia, alkalosis and hypoparathyroidism, allergic diseases, magnesium poisoning, fluorosis, cardiac resuscitation (abnormal cardiac function caused by hyperkalemia, hypocalcemia or calcium channel blocking).

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PHARMACOLOGY(Mineral Supplement)

Calcium can maintain the normal excitability of the nervous and muscular systems, and promote the secretion of acetylcholine by nerve endings. When the serum calcium level declines, the normal excitability of nervous and muscular systems can be increased, but if the serum calcium level is high, excitability is declined. Calcium ions can change the cell membrane permeability, increase capillary compactness, decrease exudation, and have an anti-allergic function. Calcium ions can promote skeletal and teeth calcification. Calcium ions can promote skeletal and teeth calcification. High concentrations of calcium and magnesium ions exist in competitive antagonism, so it can be used to treat magnesium poisoning. Calcium ions and fluorine can form insoluble calcium fluoride, so it can be used to treat fluorine poisoning. Approximately 45% of the serum calcium is bound to plasma proteins, and normal total serum calcium concentration ranges from 2.25-2.5mmoll (9-11mg/100ml). The active metabolite of parathyroid hormone, Calcitonin, and Vitamin D can maintain the stability of blood calcium content. Calcium is excreted mainly by feaces (approximately 80%), and partly by urine (approximately 20-30%). It can also be secreted in sweat, bile, saliva, and milk. Vitamin D promotes the absorption of calcium.

INDICATION:

Calgonate Injection can be used to treat tetany caused by therapeutic calcium, acute hypocalcemia, alkalosis and hypoparathyroidism, allergic diseases, magnesium poisoning, fluorosis, cardiac resuscitation (abnormal cardiac function caused by hyperkalemia, hypocalcemia or calcium channel blocking).

CONTRAINDICATIONS:

Calgonate injection is contraindicated in patients with hyperparathyroidism, Vitamin D overdose, decalcifying tumors (such as Plasmocytoma, and bone metastases), severe renal disease, and calcium loss due to immobilization. Subcutaneous and intramuscular injection is contraindicated in children.

DOSAGE AND ADMINISTRATION

1 to 2 g by intravenous injection.
Children up to 1 year, up to 300 mg: 1 to 5 years, 300-600 mg, 6 to 12 years, 600 to 1000 mg, by slow intravenous injection(IV.).
Usual Adult Dose for Hypocalcemia Intravenous (L.V.): 500 to 2000 mg (5 to 20 mL) IV one time at a rate not to exceed 0.5 to 2 mL/min.
The dose may be increased as needed. The usual daily dosage ranges from 1000 to 15,000 mg (10 to 150 ml) in divided doses or as a continuous infusion. Doses may be repeated every 1 to 3 days as needed and tolerated to normalize the serum calcium level. Usual Adult Dose for Hypermagnesemia 1000 to 2000 mg (10 to 20 mL) IV one time at a rate not to exceed 0.5 to 2 mL/min. This dose may be repeated as necessary in severe cases of hypermagnesemia (where discontinuation of exogenous magnesium is inadequate) to temporarily reverse many of the toxic effects of magnesium in the central nervous system. Usual Adult Dose for Hyperkalaemia: 500 to 3000 mg (5 to 30 mL) IV one time at a rate not to exceed 0.5 to 2 mL/min.
STORAGE: Store below 30°C. Protect from Sight
KEEP ALL MEDICINES OUT OF THE REACH OF CHILDREN

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1 Vial, Pack (10 Vials)

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